Related Experiment Videos
A concise synthesis of silanediol-based transition-state isostere inhibitors of proteases
Michael G Organ1, Christophe Buon, Carl P Decicco
1The Department of Chemistry, York University, Toronto, Ontario M3J 1P3, Canada. organ@yorku.ca
Organic Letters
|August 3, 2002
Abstract:
[reaction: see text] An efficient synthesis of silanediol-based transition-state inhibitors of proteases is described. A new convergent synthesis has been optimized by using a two-step sequence of hydrosilylation followed by the addition of a silyllithio species to an imine. The method should be applicable to the synthesis of a wide variety of silanediol isosteres to probe the utility of this unique transition-state isostere.