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Selectivity via cooperative interactions: detection of dicarboxylates in water by a pinwheel chemosensor
Joseph Raker1, Timothy E Glass
1Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
The Journal of Organic Chemistry
|August 17, 2002
Abstract:
The recognition properties of a cooperative pinwheel chemosensor for dicarboxylates are described. The sensor possesses four guanidinium recognition elements to cooperatively bind two dicarboxylates of varying size. The effect of cooperativity and the read-out mechanism contributes to favorable binding constants for dicarboxylates in water, as well as a high degree of selectivity over monocarboxylates. Appropriate methods of reporting affinity for cooperative systems are discussed.