Naproxen ion-selective electrode and its application to pharmaceutical analysis.

Area of Science:

• Analytical Chemistry
• Electrochemistry
• Pharmaceutical Analysis

Background:

• Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID).
• Accurate and efficient methods for naproxen quantification are crucial for quality control.

Purpose of the Study:

• To develop and characterize a new ion-selective membrane electrode (ISME) for naproxen determination.
• To evaluate the analytical performance and applicability of the developed ISME.

Main Methods:

• Preparation of an ion-pair complex of naproxen with methyltrioctylammonium for electrode fabrication.
• Determination of electrode characteristics: slope, measuring range, detection limit, response time, and lifetime.
• Assessment of electrode selectivity against various organic and inorganic anions.
• Application of the ISME for naproxen quantification in tablet samples using calibration curve and standard addition methods.

Main Results:

• The developed ISME exhibited a Nernstian response over a concentration range of 10⁻¹ to 10⁻⁴ mol/L.
• The electrode operated effectively within a pH range of 5.5–8.5.
• A low limit of detection (5 x 10⁻⁵ mol/L) and a short response time (20s) were achieved.
• The electrode demonstrated good selectivity for naproxen in the presence of interfering anions.

Conclusions:

• The fabricated ion-selective electrode is a reliable and sensitive tool for naproxen determination.
• The ISME provides a viable method for the analysis of naproxen in pharmaceutical formulations.
• The developed electrode offers advantages in terms of performance and simplicity for routine analysis.