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A chromoreactand for optical sensing of amphetamines.
Gerhard J Mohr1, Matthias Wenzel, Frank Lehmann
1Institute of Physical Chemistry, Friedrich-Schiller University Jena, Lessingstrasse 10, 07743 Jena, Germany. gerhard.mohr@uni-jena.de
Analytical and Bioanalytical Chemistry
|October 10, 2002
Summary
A novel bisazo dye detects amphetamine through a reversible color change from blue to red in PVC. This sensitive dye offers a low detection limit for potential field-based amphetamine testing.
Area of Science:
- Analytical Chemistry
- Materials Science
Background:
- Bisazo dyes are known for their chromogenic properties.
- Plasticised polyvinyl chloride (PVC) is a versatile polymer matrix for sensor development.
Purpose of the Study:
- To develop a colorimetric sensor for amphetamine detection.
- To investigate the reversible reaction between a bisazo dye and amphetamine in a PVC matrix.
Main Methods:
- Thin layers of plasticised PVC containing a bisazo dye were prepared.
- The color change of the dye in response to varying concentrations of amphetamine was measured.
- Spectrophotometric analysis was performed to determine sensitivity and detection limits.
Main Results:
- The bisazo dye exhibited a reversible color change from blue to red upon reaction with amphetamine.
- The sensor demonstrated sensitivity in the range of 0.3 to 30 mmol L(-1) amphetamine.
- A limit of detection of 0.1 mmol L(-1) was achieved, with maximum signal change at 630 nm.
Conclusions:
- The developed bisazo dye in PVC is a promising candidate for a simple and cost-effective amphetamine sensor.
- The compatibility with standard light sources and detectors facilitates practical applications.
- The reversible nature of the reaction allows for potential sensor regeneration or continuous monitoring.