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Effect of continuous ATP injection on human hemodynamics
Kimiaki Komukai1, Koichi Hashimoto, Takahiro Shibata
1Department of Internal Medicine, The Jikei University School of Medicine, Tokyo Japan. komu@jikei.ac.jp
Summary
Continuous adenosine triphosphate (ATP) injection for cardiac imaging can cause chest discomfort and heart block. However, ATP also increases cardiac output by affecting preload, afterload, and heart rate, with immediate recovery after infusion stops.
Area of Science:
- Cardiovascular Physiology
- Clinical Pharmacology
- Diagnostic Imaging
Background:
- Adenosine triphosphate (ATP) is clinically utilized for thallium (Tl) imaging and coronary flow assessment.
- The hemodynamic effects of continuous ATP infusion in humans remain incompletely understood.
Purpose of the Study:
- To investigate the impact of continuous adenosine triphosphate (ATP) injection on human hemodynamics during cardiac catheterization.
Main Methods:
- Hemodynamic parameters were monitored in 14 patients undergoing heart catheterization.
- Continuous intravenous infusion of ATP was administered.
Main Results:
- Continuous ATP injection led to chest symptoms in 13 patients and transient second-degree atrioventricular block in one.
- Aortic pressure decreased, while pulmonary artery pressure, right atrial pressure, and pulmonary capillary wedge pressure increased.
- Heart rate, stroke volume, and cardiac output were elevated due to increased preload, decreased afterload, and heart rate augmentation.
Conclusions:
- Continuous ATP infusion can induce transient cardiovascular symptoms and conduction disturbances.
- Despite adverse effects, ATP enhances cardiac output through complex hemodynamic modulations, with immediate resolution upon cessation of infusion.