Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phosphoinositides and the golgi complex.

Maria De Matteis1, Anna Godi, Daniela Corda

  • 1Department of Cell Biology and Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, 66030, Santa Maria Imbaro, Chieti, Italy. demattei@negrisud.it

Current Opinion in Cell Biology
|October 18, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shp1 phosphatase regulates CXCR2 protein stability and IL8-mediated invasiveness in breast cancer.

Cell death & disease·2026
Same author

<i>CMTM8</i> variants influence BNT162b2 COVID-19 vaccination response by regulating granulocytic/polymorphonuclear myeloid-derived suppressor cell activity.

Frontiers in immunology·2026
Same author

Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity.

The Journal of infectious diseases·2026
Same author

Improving our understanding of the biology of aging: findings from the Age-It Research Program.

The journals of gerontology. Series B, Psychological sciences and social sciences·2025
Same author

Mono-ADP-ribosylating PARP enzymes in cellular signaling and disease.

Journal of cell science·2025
Same author

PARP12-mediated ADP-ribosylation contributes to breast cancer cell fate by regulating AKT activation and DNA-damage response.

Cellular and molecular life sciences : CMLS·2025
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Phosphoinositides are crucial for cell signaling and membrane trafficking. Research highlights phosphatidylinositol 4-phosphate

Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Phosphoinositides serve as second messengers and membrane-binding proteins.
  • Organelle-specific lipid kinases and phosphatases create non-uniform phosphoinositide distributions.
  • Phosphoinositide pools locally regulate fundamental cellular processes, including membrane trafficking.

Purpose of the Study:

  • To investigate the role of phosphoinositides in cellular functions.
  • To explore the specific involvement of phosphatidylinositol 4-phosphate in the Golgi complex.
  • To understand the integration and control of phosphoinositide pools within organelles.

Main Methods:

  • Analysis of lipid kinase and phosphatase localization and regulation.
  • Investigating phosphoinositide distribution across cell organelles.

Related Experiment Videos

  • Studying the impact of phosphoinositides on membrane trafficking in the Golgi complex.

    • Main Results:

    • Differential regulation of lipid kinases and phosphatases leads to non-uniform phosphoinositide distribution.
    • Phosphoinositides are confirmed to locally control fundamental processes like membrane trafficking.
    • A central role for phosphatidylinositol 4-phosphate as a precursor in the Golgi complex was identified.

    Conclusions:

    • Phosphoinositides play a critical role in cellular organization and function.
    • The Golgi complex utilizes phosphatidylinositol 4-phosphate for essential processes.
    • Further research is needed to fully understand phosphoinositide pool integration and control.