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Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
05:01

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

Pathology of head trauma

John M Hardman1, Anthony Manoukian

  • 1Department of Pathology, John A. Burns School of Medicine, 1960 East-West Road, Honolulu, HI 96822, USA. hardman@hawaii.edu

Neuroimaging Clinics of North America
|October 24, 2002
PubMed

Insights

Traumatic brain injury (TBI) encompasses primary and secondary injuries from various causes, with peak incidence in the young and elderly. Understanding focal and diffuse injuries is crucial for managing TBI patients.

Area of Science:

  • Neurology
  • Pathology
  • Radiology

Background:

  • Traumatic brain injury (TBI) is a significant cause of death and disability in the United States.
  • Major causes include motor vehicle accidents, falls, assaults, and increasingly, gunshot wounds.
  • Incidences peak in infants, children, and the elderly, with certain conditions increasing accident risk.

Purpose of the Study:

  • To review primary and secondary injuries from TBI.
  • To emphasize the importance of understanding TBI pathology for patient care.
  • To highlight the role of imaging in diagnosing head trauma.

Main Methods:

  • Review of clinicopathologic studies on head injuries.
  • Assessment of incidence, severity, and etiology of TBI.
  • Correlation of imaging findings (CT and MR) with pathologic abnormalities.

Main Results:

  • TBI results in both focal lesions (e.g., contusions) and diffuse injuries.
  • Gunshot wounds to the head are a growing cause of TBI mortality.
  • Accurate interpretation of CT and MR images is vital for diagnosis.

Conclusions:

  • Understanding the pathology of both primary and secondary TBI lesions is essential for effective patient management.
  • Distinguishing between focal and diffuse injuries is critical for comprehending TBI morbidity and mortality.
  • Radiologists and forensic pathologists play key roles in diagnosing and understanding TBI.

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