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Autocrine and/or paracrine insulin-like growth factor-I activity in skeletal muscle
1Department of Physiology and Bioiphysics, C308 Medical Sciences I, University of California-Irvine, Irvine, CA 92697-4560, USA.
Abstract:
Similar to bone, skeletal muscle responds and adapts to changes in loading state via mechanisms that appear to be intrinsic to the muscle. One of the mechanisms modulating skeletal muscle adaptation it thought to involve the autocrine and/or paracrine production of insulinlike growth factor-I. This brief review outlines components of the insulinlike growth factor-I system as it relates to skeletal muscle and provides the rationale for the theory that insulinlike growth factor-I is involved with muscle adaptation.
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