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Updated: Jul 1, 2026
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Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model
Published on: April 28, 2023
[Reconstructive urethroplasty using porcine acellular matrix: preliminary results].
Franco Mantovani1, Alberto Trinchieri, Barbara Mangiarotti
1Department of Urology, IRCCS Ospedale Maggiore, Milano, Italy.
Summary
Porcine acellular matrix from small intestine submucosa shows promise for repairing long urethral strictures. This novel approach simplifies urethroplasty, offering satisfactory outcomes in preliminary patient studies.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Urology
Context:
- Urethral strictures, particularly long ones, present a reconstructive challenge.
- Current single-stage techniques often rely on autologous grafts (buccal mucosa) or flaps (preputial skin).
- Porcine acellular matrix (PAM) derived from small intestine submucosa (SIS) offers a potential alternative biomaterial.
Purpose:
- To evaluate the feasibility and efficacy of using PAM (SIS) for urethroplasty in patients with long urethral strictures.
- To report the initial clinical experience with this novel biomaterial in reconstructive urology.
Summary:
- Five patients (four male, one female) with urethral strictures (>3 cm) underwent urethroplasty using PAM (SIS).
- The matrix was shaped to the stricture length and used as a graft, with successful integration observed.
- Postoperative follow-up showed satisfactory urethral patency, normal urinary flow, and successful tissue transformation at 6 months.
Impact:
- PAM (SIS) appears to be a safe and effective biomaterial for complex urethral reconstructions.
- This technique simplifies the surgical repair of long urethral strictures.
- Encourages further investigation and application in both male and female patients.
