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Doxorubicin modulates biological effects of ATP in bone marrow cells in vitro
Yu A Uspenskaya1, A B Egorova, V P Nefedov
1Department of Anatomy and Physiology of Agricultural Animals, Krasnoyarsk State Agrarian University.
Bulletin of Experimental Biology and Medicine
|November 7, 2002
Abstract:
ATP activity in mouse bone marrow cells was studied in in vitro experiments. ATP in physiological and supraphysiological concentrations stimulated blebbing of the plasma membrane. Subacute administration of doxorubicin (inductor of oxidative stress) decreased cell sensitivity to ATP, which corresponded to changes in membrane lipid peroxidation.