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Related Experiment Videos

Lymphosarcoma, cold urticaria, IgG1 monoclonal cryoglobulin and complement abnormalities.

G Hauptmann, J M Lang, M L North

    Scandinavian Journal of Haematology
    |August 1, 1975
    PubMed
    Summary

    A patient with lymphosarcoma and cold urticaria had complement activation via the classical pathway. An IgG1 monoclonal cryoglobulin in their serum was identified as the cause.

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    Cutaneous manifestations of complement deficiencies.

    Lupus·2010

    Area of Science:

    • Immunology
    • Hematology

    Background:

    • Cold urticaria is a rare condition characterized by hives upon cold exposure.
    • Lymphosarcoma is a type of non-Hodgkin lymphoma affecting lymphoid tissues.

    Observation:

    • A patient presented with both lymphosarcoma and cold urticaria.
    • The patient exhibited low levels of early complement components and reduced C1-inhibitor.
    • The alternate complement pathway functioned normally.

    Findings:

    • Evidence of classical complement pathway activation was observed.
    • An IgG1 monoclonal cryoglobulin in the patient's serum was identified as the cause of complement activation.
    • In vitro tests confirmed the serum's high capacity to activate C1.

    Implications:

    Related Experiment Videos

    • This case highlights the link between lymphosarcoma, cold urticaria, and complement system abnormalities.
    • Understanding the role of monoclonal cryoglobulins in complement activation is crucial for managing such conditions.
    • Further research may elucidate the specific mechanisms driving complement dysregulation in this patient cohort.