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Copper(I) hydride-catalyzed asymmetric hydrosilylation of heteroaromatic ketones
Bruce H Lipshutz1, Asher Lower, Kevin Noson
1Department of Chemistry and Biochemistry, University of California-Santa Barbara, Santa Barbara, CA 93106, USA. lipshutz@chem.ucsb.edu
Organic Letters
|November 9, 2002
Abstract:
In situ generation of CuH ligated by Takasago's new nonracemic ligand, DTBM-SEGPHOS, leads to an especially reactive reagent capable of effecting asymmetric hydrosilylation of heteroaromatic (H) ketones under very mild conditions. PMHS serves as an inexpensive source of hydride. Substrate-to-ligand ratios on the order of 2000:1 are employed. [reaction: see text]