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Related Experiment Videos

Protein nitration in cardiovascular diseases.

Illarion V Turko1, Ferid Murad

  • 1Department of Integrative Biology and Pharmacology and Institute of Molecular Medicine, University of Texas Medical School, Houston, Texas 77030, USA.

Pharmacological Reviews
|November 14, 2002
PubMed
Summary

Cardiovascular disease involves reactive species that modify proteins via tyrosine nitration. Identifying nitrated proteins and their altered functions can guide antioxidant therapy and monitor treatment effectiveness.

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Area of Science:

  • Biochemistry
  • Cardiovascular Science
  • Oxidative Stress Research

Background:

  • Cardiovascular disease (CVD) is linked to increased free radicals and reactive species.
  • These reactive species can alter cellular functions and contribute to disease pathology.
  • Protein tyrosine nitration serves as a marker for in vivo reactive species production.

Purpose of the Study:

  • To review the presence of tyrosine nitrated proteins in cardiovascular tissues during disease.
  • To explore the sources and mechanisms of protein nitration in vivo.
  • To highlight the significance of identifying specific nitrated proteins and their functional changes in CVD.

Main Methods:

  • Literature review focusing on studies of protein tyrosine nitration in cardiovascular disease.

Related Experiment Videos

  • Analysis of reactive species sources and nitration mechanisms.
  • Examination of the role of nitrated proteins in physiological and pathophysiological conditions.

    • Main Results:

    • Tyrosine nitrated proteins are present in cardiovascular tissues under various disease conditions.
    • Nitration can alter protein function and metabolism, contributing to disease progression.
    • Protein nitration occurs under normal physiological conditions as well.

    Conclusions:

    • Further research is needed to identify specific proteins undergoing tyrosine nitration in CVD.
    • Understanding the link between altered protein function and pathology is crucial.
    • Targeting protein nitration may offer novel therapeutic strategies and biomarkers for CVD treatment.