Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional synaptic plasticity in hypothalamic magnocellular neurons.

Jeffrey G Tasker1, Shi Di, Cherif Boudaba

  • 1Department of Cell and Molecular Biology, Neurobiology Division, 2000 Percival Stern Hall, Tulane University, New Orleans, LA 70118, USA. tasker@tulane.edu

Progress in Brain Research
|November 20, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Norepinephrine neurons in the locus coeruleus and the nucleus of the solitary tract drive different stress-related behavioral outputs in mice.

Neurobiology of stress·2026
Same author

The emerging role of rapid corticosteroid actions on excitatory and inhibitory synaptic signaling in the brain.

Frontiers in neuroendocrinology·2024
Same author

Neuromodulation of inhibitory synaptic transmission in the basolateral amygdala during fear and anxiety.

Frontiers in cellular neuroscience·2024
Same author

Association between BMI and age at menarche or spermarche among both sexes: Findings from six successive national surveys in China.

Journal of global health·2024
Same author

Top-down control of flight by a non-canonical cortico-amygdala pathway.

Nature·2024
Same author

Multiplexed Membrane Signaling by Glucocorticoids.

Current opinion in endocrine and metabolic research·2023
Same journal

Mindfulness and meditation: Promoting emotional and cognitive health.

Progress in brain research·2025
Same journal

Cognitive stimulation enhancing memory and mental function.

Progress in brain research·2025
Same journal

The science behind non-pharmacological interventions.

Progress in brain research·2025
Same journal

Technology-assisted interventions for neuropsychiatric disorders.

Progress in brain research·2025
Same journal

Ethical consideration in non-pharmacological treatments for neuropsychiatric disorders.

Progress in brain research·2025
Same journal

The role of caregivers: Providing compassionate and effective care.

Progress in brain research·2025
See all related articles

The brain

Area of Science:

  • Neuroscience
  • Neuroendocrinology
  • Cellular Physiology

Background:

  • The hypothalamic-neurohypophysial system exhibits significant structural changes during parturition/lactation and dehydration.
  • These changes include alterations in glial coverage and synaptic innervation of magnocellular neuroendocrine cells.

Purpose of the Study:

  • To investigate the functional plasticity in synaptic physiology of magnocellular neurons.
  • To understand how these changes relate to physiological states like parturition and dehydration.

Main Methods:

  • In-vitro electrophysiological recordings from hypothalamic slices.
  • Analysis of synaptic release of neurotransmitters (glutamate and GABA).
  • Assessment of postsynaptic receptor expression and function.

Related Experiment Videos

Main Results:

  • Increased synaptic release of glutamate and GABA during lactation and dehydration.
  • Enhanced noradrenergic facilitation of glutamate release and inhibition of GABA release after dehydration.
  • Increased tonic activation of metabotropic glutamate receptors due to reduced glutamate reuptake.

Conclusions:

  • Synaptic physiology of magnocellular neurons shows profound plasticity during parturition and dehydration.
  • These plastic changes enhance neuronal excitability by modulating excitatory and inhibitory inputs and noradrenergic modulation.