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Multiple palmar epidermoid cysts
Maki Yokogawa1, Kiyofumi Egawa, Kumi Dabanaka
1Department of Dermatology, Kochi Medical School, Nankoku, Kochi, Japan. yokogawa@kochi-ms.ac.jp
Dermatology (Basel, Switzerland)
|November 22, 2002
Summary
Multiple palmoplantar epidermoid cysts in a woman were not caused by human papillomavirus (HPV). Histology revealed syringeal structures, suggesting a link to eccrine duct differentiation.
Area of Science:
- Dermatology
- Histopathology
Background:
- Epidermal cysts are typically caused by epidermal implantation.
- Palmoplantar epidermoid cysts may arise from human papillomavirus (HPV) infection or eccrine duct origins.
Observation:
- A 65-year-old woman presented with multiple, unusual epidermoid cysts on her left palm and fingers.
- Human papillomavirus (HPV) infection was ruled out via immunohistochemistry, in situ hybridization, and PCR.
Findings:
- Histological examination identified syringeal structures within the cyst walls and cavities.
- Carcinoembryonic antigen (CEA) was present in these syringeal structures.
- The cyst wall cells exhibited a cytokeratin profile similar to non-adnexal epidermis.
Implications:
- This case suggests a potential origin of palmoplantar epidermoid cysts from eccrine duct differentiation.
- The findings contribute to understanding the diverse etiologies of epidermoid cysts.
- Further research may elucidate the specific mechanisms involved in eccrine-derived cyst formation.