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Hemopoietic and lymphoid organs in AKR/JY mice with thymic lymphoma
G V Karpova1, T I Fomina, E V Abramova
1Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Bulletin of Experimental Biology and Medicine
|December 3, 2002
Abstract:
Cytological and histological studies of the thymus, bone marrow, peripheral blood, spleen, and lymph nodes in 6-9-month-old AKR/JY mice showed that the risk of thymic lymphoma in these animals increased with age. Generalization of the tumor process was observed in mice aged over 8 months and first involved the spleen, then the lymph nodes, bone marrow, and liver. A case of primary lymphoma in the spleen was detected.