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Diastereoselective synthesis of highly substituted tetrahydropyran-4-ones
Paul A Clarke1, William H C Martin
1School of Chemistry, University of Nottingham, University Park, United Kingdom. paul.clarke@nottingham.ac.uk
Organic Letters
|December 6, 2002
Abstract:
[reaction: see text] Aldol reactions of beta-ketoesters with aldehydes followed by a tandem Knoevenagel condensation, with a further equivalent of aldehyde, and intramolecular Michael addition produces single diastereomers of highly substituted tetrahydropyran-4-ones.