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Related Experiment Videos

Apelin expression in normal human tissues.

Maria De Falco1, Luca De Luca, Nicoletta Onori

  • 1Department of Evolutive and Comparative Biology, University Federico II, Naples, Italy.

In Vivo (Athens, Greece)
|December 24, 2002
PubMed
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Apelin, a peptide hormone, interacts with the APJ receptor. This study reveals apelin

Area of Science:

  • Biochemistry
  • Endocrinology
  • Cell Biology

Background:

  • Apelin is an endogenous ligand for the orphan G protein-coupled receptor APJ.
  • Apelin is derived from a 77-amino acid precursor and exists in multiple forms.
  • Known functions include regulation of blood pressure and blood flow, and modulation of cytokine production.

Purpose of the Study:

  • To investigate the distribution of apelin in various human tissues.
  • To understand the broader physiological roles of the apelin-APJ system.

Main Methods:

  • Immunohistochemistry was employed to detect apelin.
  • Analysis was performed on multiple human tissue samples.

Main Results:

  • Apelin demonstrated a widespread expression pattern across human tissues.

Related Experiment Videos

  • The findings suggest extensive interactions between apelin and its receptor APJ in vivo.

    • Conclusions:

    • Apelin plays a significant role in various physiological processes due to its broad tissue distribution.
    • The apelin-APJ system is a key player in human physiology.