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[Extracellular ATP: effects, sources and fate]
Y H Huang1, X H Weng, Z Q Zhou
1Department of Physiology and Biophysics, College of Life Sciences, Peking University, Beijing 100871.
Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|December 28, 2002
Summary
Extracellular adenosine triphosphate (ATP) is a key transmitter influencing physiological functions. This review details ATP
Area of Science:
- Biochemistry and Molecular Biology
- Neuroscience
- Cell Signaling
Context:
- Extracellular adenosine triphosphate (ATP) plays a critical role in physiological processes.
- ATP functions as a neurotransmitter at neuro-effector junctions, modulating neurotransmitter release.
- Extracellular ATP impacts cell activities via P2-purinoceptors and ionic channels.
Purpose:
- To review recent advancements in understanding extracellular ATP.
- To cover the discovery and confirmation of ATP as a transmitter.
- To explore P2-purinoceptor subtypes, their mediated reactions, and ATP degradation.
Summary:
- This review synthesizes current knowledge on extracellular adenosine triphosphate (ATP).
- It examines ATP's role as a neurotransmitter and its effects on cell signaling.
- Key areas include ATP sources, P2-purinoceptor subtypes, signaling pathways, and degradation mechanisms.
Impact:
- Provides a comprehensive overview of extracellular ATP research.
- Highlights the significance of ATP in physiological functions and cell communication.
- Offers insights into potential therapeutic targets related to purinergic signaling.