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Updated: Sep 28, 2026

Imaging of Intracellular ATP in Organotypic Tissue Slices of the Mouse Brain using the FRET-based Sensor ATeam1.03YEMK
Published on: December 19, 2019
[Extracellular ATP: effects, sources and fate]
Y H Huang1, X H Weng, Z Q Zhou
1Department of Physiology and Biophysics, College of Life Sciences, Peking University, Beijing 100871.
Abstract:
The change of extracellular adenosine triphosphate (ATP) concentration affects many important physiological functions significantly. As a transmitter, ATP acts on neuro-effector junction directly and/or modulates the release of other neurotransmitters. By acting on the various P2-purinoceptors or ionic channels on the membrane, ATP also has some striking effects on cell activities. This review focused on the latest advances on the research of extracellular ATP in the respects of discovering and confirming ATP as a transmitter, the source, subtypes of P2-purinoceptors, the receptor-mediated reactions, and the degradation of extracellular ATP.
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