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Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis
A S Saratikov1, T P Novozheeva, R R Akhmedzhanov
1Department of Pharmacology, Siberian State Medical University, Tomsk. albert@post.tomica.ru
Bulletin of Experimental Biology and Medicine
|January 4, 2003
Abstract:
Inductors of the monooxygenase system benzonal, halonal, and halodif prevented the development of intrahepatic cholestasis induced by a-naphthylisothiocyanate and stimulated detoxifying function of the liver in rats. These agents increased the content of microsomal protein and cytochrome P-450 and accelerated metabolism of types I and II substrates. This was accompanied by a decrease of serum concentrations of total and free bilirubin and activity of liver-specific enzymes. Phenobarbital did not prevent the development of hepatocyte cytolysis.