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Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse
Robert S Tan1, Deepa Vasudevan
1Department of Family and Community Medicine, University of Texas Health Sciences Center, Houston, Texas 77030, USA. robert.s.tan@uth.tmc.edu
Objective:
To report a case of symptomatic hypogonadism induced by the abuse of multiple steroid preparations that was subsequently reversed by clomiphene.
Design:
Case report.
Setting:
University-affiliated andrology practice within family practice clinic.
Patient(S):
A 30-year-old male.
Intervention(S):
Clomiphene citrate, 100-mg challenge for 5 days, followed by treatment at same dose for 2 months.
Main Outcome Measure(S):
Clinical symptoms, androgen decline in aging male questionnaire, total T, FSH, LH.
Result(S):
Reversal of symptoms, normalization of T levels with LH surge, restoration of pituitary-gonadal axis.
Conclusion(S):
Clomiphene citrate is used typically in helping to restore fertility in females. This represents the first case report of the successful use of clomiphene to restore T levels and the pituitary-gonadal axis in a male patient. The axis was previously shut off with multiple anabolic steroid abuse.