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Related Experiment Videos

Myocardial tagging with SSFP.

Daniel A Herzka1, Michael A Guttman, Elliot R McVeigh

  • 1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. herzkad@nih.gov

Magnetic Resonance in Medicine
|January 24, 2003
PubMed
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This study introduces myocardial tagging using refocused steady-state free precession (SSFP), improving cardiac function measurements. SSFP tagging offers better contrast and tag persistence than standard methods, enhancing diagnostic capabilities.

Area of Science:

  • Cardiovascular Magnetic Resonance Imaging
  • Biomedical Engineering
  • Medical Physics

Background:

  • Myocardial tagging is crucial for quantitative assessment of cardiac function.
  • Current fast gradient-echo (FGRE) tagging protocols have limitations in contrast and tag persistence.
  • Steady-state free precession (SSFP) offers high signal-to-noise ratio (SNR) but its application in tagging is novel.

Purpose of the Study:

  • To implement and evaluate myocardial tagging using refocused SSFP with magnetization preparation.
  • To compare the performance of SSFP tagging against conventional FGRE tagging.
  • To investigate the impact of imaging parameters, specifically flip angle (alpha), on SSFP tagging efficacy.

Main Methods:

  • Development of a novel myocardial tagging sequence combining refocused SSFP and magnetization preparation.

Related Experiment Videos

  • Quantitative comparison of myocardium-tag contrast-to-noise ratio (CNR) and tag persistence between SSFP and FGRE techniques.
  • Utilized numerical simulations, phantom studies, and human experiments for validation.
  • Evaluated the effect of varying flip angle (alpha) and receiver bandwidth (RBW) on imaging outcomes.

    • Main Results:

    • SSFP tagging demonstrated improved myocardium-tag CNR and tag persistence compared to FGRE.
    • Both CNR and tag persistence decreased with increasing flip angle (alpha) due to tag decay and signal reduction.
    • Higher alpha values enhanced blood-myocardium contrast, while lower alpha values improved tag persistence.
    • SSFP tagging achieved comparable or superior CNR to FGRE at equivalent or higher receiver bandwidths.
    • SSFP acquisition allowed for reduced breath-hold times or increased temporal resolution.

    Conclusions:

    • Refocused SSFP myocardial tagging is a viable and improved alternative to FGRE tagging.
    • The choice of flip angle (alpha) in SSFP tagging should be application-dependent for optimal results.
    • SSFP tagging enhances cardiac function assessment through improved image quality and acquisition efficiency.