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[An electrophysiological study of the kainic acid toxicity on cochleas]
1Department of Otorhinolaryngology, Union Hospital, Tongji Medical University, Wuhan 430022.
Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology
|January 25, 2003
Abstract
Objective:
The purpose of this study was to investigate the kainic acid (KA) toxicity on cochleas.
Method:
One microliter KA in the concentration of 60 mM was applied to the round window membrane of guinea pig. The compound action potential (CAP), cochlear microphonic potential (CM) and distortion product otoacoustic emissions (DPOAE) were measured 12 hours after KA was administrated.
Result:
CAP was suppressed significantly or abolished after the drug administration, however, the CM and DPOAE almost presented no change.
Conclusion:
The targets of KA toxicity are the primary auditory afferent endings.