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[The immunologic study on local nasal immunotherapy for perennial allergic rhinitis]
1Department of Otorhinolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029.
Objective:
To investigate the clinical efficacy and immune mechanism of local nasal immunotherapy (LNIT).
Method:
142 cases of perennial allergic rhinitis (PAR) were treated with LNIT. Immunologic study was carried out in 30 cases.
Result:
LNIT was as effective as traditional subcutaneous immunotherapy (P > 0.05). Immunologic study demonstrated, that the nasal secretory IgA (S-IgA) increased significantly after treatment (P < 0.05). The levels of nasal secretory total IgE, serum total IgE and serum specific IgE (anti-mite, ragweed pollon) decreased, but there was no significance (P > 0.05).
Conclusion:
LNIT can improve the local immune function and modify the local nasal allergic inflammatory response. It is an effective, safe and convenient treatment.