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[Detection of S-100 protein in laryngeal carcinoma]
1Department of Otolaryngology, Sir Run Run Shaw Hospital, Medical Center of Zhejiang University, Hangzhou 310016.
Objective:
To study the relationship between S-100 protein and prognosis of laryngeal carcinoma.
Method:
S-100 protein was observed by immunohistochemical methods using anti-S-100 protein antibody in 68 laryngeal carcinoma and 21 non-cancer laryngeal tissues.
Result:
The result showed that S-100 protein positive were found 43 (63.24%) in 68 laryngeal carcinoma. S-100 protein positive cells were interspersed among the tumor cells and in the stroma. S-100 protein were rare in non-cancer laryngeal tissues. The five-year survival rate in patients with S-100 protein positive was significantly higher than that in patients with S-100 protein negative.
Conclusion:
Our result indicated that the detection of S-100 protein is of value for the prognostic analysis in patients with laryngeal carcinoma.
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