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[Recognizing of the transglottic carcinoma]
1Department of Otorhinolaryngology, Affiliated Ganquan Hospital of Shanghai, Tiedao University, Shanghai 200065.
Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology
|January 25, 2003
Summary
Transglottic carcinoma (TGC) is a distinct laryngeal cancer type. Its unique paraglottic space topography influences spread, necessitating elective neck dissection and postoperative radiotherapy for improved outcomes.
Area of Science:
- Otolaryngology
- Oncology
- Pathology
Context:
- Transglottic carcinoma (TGC) presents unique diagnostic and therapeutic challenges within laryngeal malignancies.
- Understanding the specific anatomical involvement of the paraglottic space (PGS) is crucial for TGC management.
Purpose:
- To characterize transglottic carcinoma (TGC) as a distinct entity within laryngeal cancers.
- To analyze the patterns of disease spread, treatment modalities, and survival rates in TGC cases.
Summary:
- Retrospective analysis of 86 transglottic carcinoma (TGC) cases from 1979-1998.
- Surgical interventions included total laryngectomy (63), subtotal laryngectomy (9), and frontolateral hemilaryngectomy (14), with 47 cases undergoing neck dissection.
- TGC cases >2 cm showed significant laryngeal framework extension (58%), extralaryngeal spread (46%), and high rates of neck metastasis (71%). Five, 10, and 15-year survival rates were 55.41%, 29.72%, and 18.92%, respectively.
Impact:
- Confirms TGC as a unique laryngeal carcinoma subtype with specific prognostic factors.
- Highlights the importance of the paraglottic space (PGS) in TGC's invasive behavior and metastasis.
- Recommends elective neck dissection and adjuvant radiotherapy as standard components of TGC treatment protocols.