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[Immunohistological observation of tonsillae in IgA nephropathy]
1Department of Otorhinolaryngology, General Hospital of Nanjing Command, PLA, Nanjing 210002.
Objective:
To realize the relationship between IgA nephropathy (IgA-N) and immunological abnormality of tonsillae.
Method:
Thirty-one patients were diagnosed as IgA-N via renal puncture. Sixteen patients suffering from chronic tonsillitis as control. All resected tonsillae were labelled immunohistologically by ABC method.
Result:
The differences of expression of IgA, IgG in the tonsillae between above two groups were significantly obvious. The number of lymphocytes which can produce IgA increased in IgA-N tonsillae.
Conclusion:
The immune functions are abnormal in IgA-N patients. Tonsillectomy can prevent the antigen invasion, eliminate IgA originated from tonsillae, decrease the IgA immunocomplex in circulation, therefore decrease the IgA immunocomplex deposition in the basal membrane of glomeruli.
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