When neurons form memories
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Updated: Sep 27, 2026

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
Published on: June 23, 2022
Pascal Fries1, Guillén Fernández, Ole Jensen
1F.C. Donders Centre for Cognitive Neuroimaging, Adelbertusplein 1, 6525 EK Nijmegen, The Netherlands. pascal.fries@fcdonders.kun.nl
Abstract:
Although long-term memory is central among our cognitive functions, the search for a direct neurophysiological correlate to it has proven difficult. The formation of new memories depends on the hippocampus and adjacent cortex, but the final storage is thought to be in a widely distributed neocortical network. Recent experiments, using simultaneous recordings from hundreds of sites in monkey neocortex, have revealed the activation of such a distributed network -- probably reflecting the consolidation of long-term memory storage.
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