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Diastereoselective titanium enolate aldol reaction for the total synthesis of epothilones
Guido Koch1, Olivier Loiseleur, Daniel Fuentes
1Novartis Pharma AG, Process R&D and BU Oncology, Postfach CH-4002 Basel, Switzerland. guido.koch@pharma.novartis.com
Organic Letters
|February 26, 2003
Abstract:
[formula: see text] The development of a highly diastereoselective addition of the titanium enolate derived from ketone 1 to aldehyde 2 offers an efficient entry to the total synthesis of the epothilone family. The new aldol process is robust and tolerates a wide range of functional groups.