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[Effects of nimodipine on cochlear blood flow with normal and vertebrobasilar insufficiency status]
Furong Ma1, Xuepei Li, Yimin Zhao
1Department of Otolaryngology, Third Hospital of Beijing University, Beijing 100083.
Objective:
To study effect of nimodipine (ND) on cochlear blood flow (CBF).
Method:
CBF was measured in twenty-two guinea pigs by laser Doppler flowmetry(LDF).
Result:
Nimodipine decreased CBF following the decrease of systemic BP and present a dose dependent mode, neither the dose of nimodipine is lower, normal and higher, nor the animal is under the status of normal supply of inner ear blood flow and ischemia of inner ear caused by vertebrobasilar insufficiency(VBI).
Conclusion:
It suggested that this compound may be of little clinical use to elevate CBF.
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