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Dry eye and delayed tear clearance: "a call to arms."
Stephen C Pflugfelder1, Abraham Solomon, Dilek Dursun
1Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine Houston, Texas, USA.
Advances in Experimental Medicine and Biology
|March 5, 2003
Abstract:
Dry eye may activate components of the ocular surface early warning system. Ocular surface stresses in dry eye, such as hyperosmolarity, could activate cellular stress pathways such as MAPKs. IL-1 and MMP-9 produced by the ocular surface epithelial cells may mediate initial events in the inflammatory cascade of dry eye through a dynamic interplay between them on the ocular surface.