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Association of HLA-DR and type II collagen autoimmunity with Meniere's disease

J-W Koo1, S H Oh, S O Chang

  • 1Department of Otolaryngology, Department of Clinical Pathology, Seoul National University College of Medicine, Seoul, Korea.

Tissue Antigens
|March 8, 2003
PubMed

Insights

Human leukocyte antigen (HLA) type II collagen autoimmunity may play a role in Meniere

Area of Science:

  • Immunogenetics
  • Otolaryngology
  • Rheumatology

Background:

  • Meniere's disease is a complex inner ear disorder with potential autoimmune links.
  • Type II collagen (CII) autoimmunity has been implicated in some cases of Meniere's disease.
  • Human leukocyte antigen (HLA) genes are crucial in immune responses and disease susceptibility.

Purpose of the Study:

  • To investigate the association between HLA-DRB1 alleles and Meniere's disease in relation to anti-CII antibody status.
  • To identify specific HLA-DRB1 alleles conferring susceptibility or resistance to Meniere's disease.
  • To explore shared genetic factors between anti-CII positive Meniere's disease and rheumatoid arthritis.

Main Methods:

  • HLA-DRB1 genotyping was performed on 41 Korean Meniere's disease patients and controls.
  • Enzyme-linked immunosorbent assay (ELISA) was used to measure anti-CII antibodies.
  • Statistical analysis compared allele frequencies between patient subgroups and controls.

Main Results:

  • The HLA-DRB1*0405 allele was significantly increased in anti-CII positive Meniere's patients compared to controls and anti-CII negative patients.
  • HLA-DRB1*1201 was associated with susceptibility, while HLA-DRB1*13 showed a resistance association in the anti-CII negative subgroup.
  • The QRRAA sequence in HLA-DRB1*0405 may be a shared genetic susceptibility factor with anti-CII positive rheumatoid arthritis.

Conclusions:

  • Type II collagen autoimmunity may contribute partially to Meniere's disease pathogenesis.
  • Specific HLA-DRB1 alleles are associated with susceptibility or resistance to Meniere's disease, depending on anti-CII antibody status.
  • Shared genetic factors, like the QRRAA sequence, might link anti-CII positive Meniere's disease and rheumatoid arthritis.

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