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[Naphazoline intoxication: course and therapy].

S Wenzel1, G Laux, C Sagowski

  • 1Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Hamburg-Eppendorf, Hamburg. swenzel@uke.uni-hamburg.de

Laryngo- Rhino- Otologie
|March 8, 2003
PubMed
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Naphazoline, an imidazoline derivative, can cause severe systemic side effects. Phentolamine is a symptomatic treatment for naphazoline intoxication, highlighting the need for strict dosage adherence.

Area of Science:

  • Pharmacology
  • Toxicology
  • Adrenergic Agonists

Background:

  • Naphazoline, an imidazoline derivative, acts as an alpha-adrenergic agonist with vasoconstrictive and decongestant properties.
  • While effective, naphazoline can cause local and rare systemic side effects including hypertension, excitability, and nausea.
  • Severe intoxication can lead to organ ischemia, bradycardia, respiratory depression, hypothermia, and altered mental status.

Observation:

  • This report details two cases of naphazoline intoxication following its use for hemostasis during surgery.
  • The cases describe the postoperative course and management strategies employed for these patients.

Findings:

  • No specific antidote exists for naphazoline intoxication.
  • Symptomatic treatment with intravenous phentolamine (an alpha-adrenoceptor antagonist) can counteract vasoconstrictive effects.

Related Experiment Videos

  • Effective management requires careful monitoring and supportive care.

    • Implications:

    • The narrow therapeutic-to-toxic window of naphazoline necessitates strict adherence to dosage guidelines and contraindications.
    • Healthcare providers must be vigilant regarding potential systemic toxicity, even with topical application.
    • Awareness of naphazoline's adverse effects is crucial for safe clinical practice and patient outcomes.