Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Techniques: Visualizing apoptosis using nuclear magnetic resonance.

Juhana M Hakumäki¹, Kevin M Brindle

¹Department of Biomedical NMR, National Bio-NMR Facility, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, PO Box 1627, FIN-70211 Kuopio, Finland. juhana.hakumaki@uku.fi

Trends in Pharmacological Sciences

|March 12, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Patatin-like phosphatase domain-containing 3 genotype and quality of dietary fat modify the liver adiposity in men.

European journal of nutrition·2026

Same author

Imaging the hallmarks of cancer.

Nature reviews. Cancer·2026

Same author

Imaging progenitor cell differentiation during central nervous system remyelination using an MRI gene reporter.

Brain : a journal of neurology·2026

Same author

Modeling of Fiber Orientation-Dependent R1 Relaxation in Human White Matter In Vivo Within The Framework of The Transient Hydrogen Bond Model.

Magnetic resonance in medicine·2026

Same author

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Same author

Imaging progenitor cell differentiation during central nervous system remyelination using an MRI gene reporter.

bioRxiv : the preprint server for biology·2025

Same journal

Targeting developmental reprogramming: hPSC insights for cancer interception.

Trends in pharmacological sciences·2026

Same journal

July 2026 issue first authors.

Trends in pharmacological sciences·2026

Same journal

Chronobiomaterials for circadian-aligned brain therapeutics.

Trends in pharmacological sciences·2026

Same journal

Biosensors for translatable GPCR bias.

Trends in pharmacological sciences·2026

Same journal

ECM stiffness and epigenetics in organ fibrosis.

Trends in pharmacological sciences·2026

Same journal

Which HTT transcript to lower?

Trends in pharmacological sciences·2026

See all related articles

Nuclear magnetic resonance (NMR) techniques like spectroscopy (MRS) and imaging (MRI) now detect apoptosis in living cells. These advancements aid in developing new anticancer drugs and monitoring treatment effectiveness.

Area of Science:

Biophysics
Oncology
Biochemistry

Background:

Apoptosis is crucial in tumor biology and a primary target for cancer therapies.
Traditional Nuclear Magnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Imaging (MRI) are vital in chemistry and clinical diagnostics.

Purpose of the Study:

To explore novel applications of MRS and MRI beyond their conventional uses.
To investigate the potential of advanced MR techniques in detecting and understanding apoptosis in living systems.

Main Methods:

Utilizing advanced Nuclear Magnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Imaging (MRI) techniques.
Applying these MR methods to living cells and tissues to observe apoptotic processes.

Main Results:

Related Experiment Videos

Demonstrated the capability of new MR techniques to detect previously unobservable biological phenomena during apoptosis.
Showcased the transition of MRS and MRI from structural analysis to dynamic biological process monitoring.

Conclusions:

Advanced MRS and MRI offer new insights into apoptosis.
These MR techniques hold significant promise for novel anticancer drug development and enhanced clinical treatment response detection.