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Alkaline hydrolysis of cladribine
M Andrzejewska1, A Dzierzgowska-Szmidt, Z Kazimierczuk
1Institute of Chemistry, Agricultural University, Warsaw, Poland.
Die Pharmazie
|March 19, 2003
Abstract:
The kinetics of hydrolysis of 2-chloro-2'-deoxyadenosine (cladribine) was studied at various sodium hydroxide concentrations and temperatures. HPLC analysis of reaction mixtures showed that the main products were 2'-deoxyisoguanosine and 2'-deoxyguanosine. The first one was the result of the hydroxyl anion attack, whereas the presence of the other nucleoside has evidenced the existence of hitherto undescribed rearrangement reaction in purine derivatives.