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Updated: Aug 8, 2026
11:10
Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
Subcutaneous glucose sensor values closely parallel blood glucose during insulin-induced hypoglycaemia
N J Caplin1, P O'Leary, M Bulsara
1Department of Diabetes & Endocrinology, Princess Margaret Hospital for Children, Perth, Western Australia. neilcaplin@hotmail.com
Summary
The Minimed continuous glucose monitoring system (CGMS) accurately estimates blood glucose in adolescents during controlled hypoglycemia. A slight difference was observed at glucose levels below 3.3 mmol/l.
Area of Science:
- Endocrinology
- Biomedical Engineering
- Diabetes Technology
Background:
- Continuous Glucose Monitoring Systems (CGMS) are vital for diabetes management.
- Accurate glucose estimation is crucial, especially during rapid glucose changes.
Purpose of the Study:
- To evaluate the accuracy of the Minimed CGMS in estimating blood glucose levels.
- To assess CGMS performance during controlled hypoglycemia in adolescents.
Main Methods:
- Nine adolescent diabetics participated in hyperinsulinemic hypoglycemic clamp studies.
- CGMS glucose values were compared against venous blood samples analyzed via glucose oxidase technique.
Main Results:
- A total of 429 paired measurements were analyzed.
- Mean difference between CGMS and blood glucose was 0.13 mmol/l, with blood glucose slightly higher.
- The discrepancy was most notable at blood glucose levels < 3.3 mmol/l.
Conclusions:
- The Minimed CGMS provides an accurate reflection of blood glucose during systemic glucose decline.
- A minor difference exists between sensor and blood glucose readings below 3.3 mmol/l.
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