Skin metastasis from prostate adenocarcinoma

Area of Science:

• Oncology
• Urology
• Dermatology

Background:

• Prostate adenocarcinoma typically metastasizes to bone.
• Skin metastasis from prostate cancer is rare.

Observation:

• A patient with hormone-refractory prostate adenocarcinoma presented with skin metastasis.
• Bone metastasis was notably absent on radioisotope bone scan.
• Prostate-specific antigen (PSA) levels were within the normal range.

Findings:

• The patient received mitoxantrone and prednisolone chemotherapy.
• Lung metastasis developed after two cycles of chemotherapy.
• The patient succumbed to progressive disease four months later.

Implications:

• This case underscores the diverse metastatic patterns of prostate adenocarcinoma.
• It highlights the importance of considering unusual presentations in advanced prostate cancer.
• Further research into the mechanisms of non-osseous metastasis in prostate cancer is warranted.