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Updated: Sep 26, 2026

Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO2 Source
Published on: August 17, 2018
No stirring necessary: parallel carbonylation of aryl halides with CO and various alcohols under pressure
Hans-Ulrich Blaser1, Martin Diggelmann, Hans Meier
1Solvias AG, R-1055.6, CH-4002 Basel, Switzerland.
Abstract:
The parallel carbonylation of aryl halides with 6-25 bar of CO in 1-mL vials in a standard autoclave was investigated. 4-Bromoacetophenone and 2-chloropyridine were used as model substrates with 102 different O-nucleophiles (primary and secondary alcohols, phenols). No inertization during the loading was necessary. Fifty esters (43 new, yield up to 60%) were isolated and characterized. Ether, ester, ketone, and sometimes even olefin functions were usually tolerated. The new method is suitable for screening and small scale products synthesis.
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