Related Experiment Video
Updated: Jul 12, 2026
13:10
Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay
Published on: June 9, 2017
The DNA damage checkpoint and human cancer
L B Schultz1, N H Chehab, A Malikzay
1Wistar Institute, Graduate Program in Biomedical Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Cold Spring Harbor Symposia on Quantitative Biology
|May 23, 2003
Summary
No abstract available in PubMed .
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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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