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New sesquiterpene quinols from a Micronesian sponge, Aka sp
Venugopal J R V Mukku1, Ru A Edrada, Francis J Schmitz
1Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.
Journal of Natural Products
|May 24, 2003
Abstract:
Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.