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Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases
Published on: November 21, 2010
Crystallography of membrane proteins, major targets in drug design
1Institut de Recherches Microbiologiques JM Wiame, 1 Av E.Gryson, B-1070 Brussels, Belgium. jwouters@dbm.ulb.ac.be
Abstract:
Protein crystallography has the potential to accelerate drug discovery greatly. High-resolution structures of membrane proteins of pharmaceutical interest open new perspectives in drug design. Recent structural data obtained for cyclooxygenases, monoamine oxidase, squalene cyclase, rhodopsine, porins, aquaporins, and ABC transporters are presented and briefly discussed.
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