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Zopiclone-induced acute interstitial nephritis.
Naser Hussain1, Martin MacKinnon, Ayub Akbari
1Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Summary
Zopiclone, a hypnotic drug, can cause acute interstitial nephritis, leading to kidney failure. Early identification and treatment with corticosteroids can restore kidney function.
Area of Science:
- Nephrology
- Pharmacology
Background:
- Zopiclone is a commonly prescribed nonbenzodiazepine hypnotic for insomnia.
- Short-acting hypnotics are frequently used for sleep disorders.
Observation:
- A young, healthy male developed anuric acute renal failure.
- The patient required hemodialysis due to kidney dysfunction.
Findings:
- Kidney biopsy revealed acute interstitial nephritis with eosinophilic infiltrate.
- Zopiclone was identified as the causative agent.
Implications:
- Prompt medication cessation and corticosteroid treatment led to renal function recovery.
- Highlights the potential for zopiclone to induce severe kidney injury.
- Emphasizes the importance of considering drug-induced nephrotoxicity in acute renal failure.