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Quantitative proteome analysis: methods and applications.

Ruedi Aebersold1

  • 1Institute for Systems Biology, Seattle, Washington 98103, USA. raebersold@systemsbiology.org

The Journal of Infectious Diseases
|June 7, 2003
PubMed
Summary
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Genomic sequencing advances drive interest in interpreting biological data. Quantitative proteome analysis offers a method to study protein expression changes, with new high-throughput technology enabling complex mixture profiling.

Area of Science:

  • Genomics and Proteomics
  • Systems Biology

Background:

  • Genomic sequencing of multiple species, including humans, necessitates methods for interpreting biological information.
  • Understanding biologic systems requires knowledge of protein structure, function, and regulation.
  • Quantitative proteome analysis is emerging as a key technique for studying protein expression.

Purpose of the Study:

  • To describe the rationale behind quantitative proteome analysis.
  • To introduce a novel high-throughput technology for quantitative protein profiling.
  • To present current applications and status of this new technology.

Main Methods:

  • Global analysis of protein expression.
  • Quantitative proteome analysis for studying protein profiles.

Related Experiment Videos

  • High-throughput quantitative profiling of proteins in complex mixtures.

    • Main Results:

    • The study describes the rationale for quantitative proteome analysis.
    • A new technology for high-throughput quantitative protein profiling is presented.
    • Selected applications of the technology are discussed.

    Conclusions:

    • Quantitative proteome analysis is crucial for interpreting genomic data.
    • The new high-throughput technology facilitates detailed protein profiling.
    • This approach aids in understanding biologic systems and processes.