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Isolation of Leukocytes from the Human Maternal-fetal Interface
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Published on: May 21, 2015

Expression of cytokine genes in adhesions on uterine tubes

A V Zhdanov1, M P Davydova, T G Gabuniya

  • 1Research Center for Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.

Bulletin of Experimental Biology and Medicine
|June 13, 2003
PubMed

We studied expression of genes of interleukins, interferon-gamma, tumor necrosis factor-alpha, and transforming growth factor-beta(2) in adhesions on uterine tubes. In tubal adhesions the intensity of production of mRNA for proinflammatory cytokines, antiinflammatory cytokine interleukin-10, and regulator of cell proliferation surpassed that in normal tissues by 2.5-7.4, 2.2, and 50.2 times, respectively. Correlations were found between production of mRNA for tumor necrosis factor-alpha and transforming growth factor-beta(2), interleukin-12, and interferon-gamma and interleukin-12 and transforming growth factor-beta(2). Our results suggest that expression of these genes during adhesion formation is regulated by the feedback mechanism.

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