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Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis
05:37

Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis

Published on: December 22, 2017

Sinovenous thrombosis in children

Manohar Shroff1, Gabrielle deVeber

  • 1Department of Diagnostic Imaging, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

Neuroimaging Clinics of North America
|June 14, 2003
PubMed

Insights

Childhood cerebral sinovenous thrombosis (CSVT) is a serious condition often missed. Early diagnosis and anticoagulation treatment are crucial for improving outcomes and reducing long-term neurological deficits in children.

Area of Science:

  • Pediatric Neurology
  • Vascular Neurology
  • Medical Imaging

Background:

  • Childhood cerebral sinovenous thrombosis (CSVT) is increasingly recognized but frequently misdiagnosed.
  • Neonates face a substantially higher risk of CSVT and associated severe sequelae compared to older children.
  • CSVT in children results in significant long-term adverse outcomes, including death or neurological deficits in nearly 50% of cases.

Purpose of the Study:

  • To review the current understanding and management of childhood CSVT.
  • To highlight the importance of early diagnosis and effective treatment strategies.
  • To discuss the role of advancing neuroimaging in improving detection and understanding of CSVT.

Main Methods:

  • Literature review focusing on epidemiology, pathophysiology, diagnosis, and treatment of childhood CSVT.
  • Analysis of current treatment approaches, including the growing evidence for anticoagulation.
  • Evaluation of the impact of evolving neuroimaging techniques on CSVT diagnosis and research.

Main Results:

  • Childhood CSVT presents diagnostic challenges, with neonates being a particularly high-risk group.
  • Anticoagulation is increasingly supported as a treatment due to unacceptable adverse outcomes with empiric management.
  • Advancements in noninvasive, economical neuroimaging are expected to improve detection rates and patient stratification.

Conclusions:

  • Childhood CSVT requires heightened clinical awareness for timely diagnosis.
  • Evidence supports anticoagulation therapy for CSVT in children, mirroring adult treatment protocols.
  • Future multi-national trials, aided by improved neuroimaging, are essential for evidence-based treatments and reduced morbidity/mortality.

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