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Preparation, X-ray structure and reactivity of a stable glycosyl iodide
Jamie Bickley1, Jennifer A Cottrell, John R Ferguson
1The Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool, UK L69 7ZD.
Chemical Communications (Cambridge, England)
|June 18, 2003
Abstract:
Highly selective reaction of methyl tetra-O-pivaloyl-beta-D-glucopyranuronate 2 with iodotrimethylsilane or (Me3Si)2 and I2 affords, in excellent yield, the 'disarmed' glycosyl iodide 1 which has good stability at 20 degrees C and excellent stability at 0 degrees C; the X-ray crystal structure of 1 is described, along with a comparison of its utility as a glycosyl donor to that of the corresponding bromide.