Jove
Visualize
Contact Us

Related Experiment Videos

Arthritis in the rabbit knee joint: a quantitated model.

C V DeShazo, M M DeShazo

    Rheumatology
    |January 1, 1975
    PubMed
    Summary

    Rabbit knee joints model acute immunologic arthritis. Neutrophil depletion and complement component reduction significantly decreased Arthus lesions, demonstrating their role in immune complex-induced joint injury.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hold or fold?

    Physician executive·2001
    Same author

    Renal transplantation with blood supply by axillofemoral bypass graft.

    American journal of surgery·1976
    Same author

    Results of renal transplantation in 100 children.

    Surgery·1974
    Same author

    Double renal transplants from pediatric donors to adult recipients.

    American journal of surgery·1974
    Same author

    Mucosal pedicle graft of jejunum for large gastroduodenal defects.

    American journal of surgery·1972
    Same author

    The effect of complement depletion on neutrophil migration in acute immunologic arthritis.

    Journal of immunology (Baltimore, Md. : 1950)·1972
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Immunology
    • Rheumatology
    • Pathology

    Background:

    • The rabbit knee joint serves as a valuable model for studying acute immunologic injuries, particularly arthritis.
    • Histological examination of synovium and joint lavage enables detailed analysis of damage mechanisms.

    Purpose of the Study:

    • To investigate the role of neutrophils and complement in immune complex-induced arthritis using a rabbit knee joint model.
    • To characterize Arthus-type vascular lesions and their modulation by specific immune components.

    Main Methods:

    • Utilized a rabbit knee joint arthritis model.
    • Performed histological examination of synovium.
    • Employed joint lavage to collect inflammatory exudate.
    • Manipulated neutrophil levels (depletion and reconstitution) and complement components.

    Main Results:

    • Arthus lesions in the rabbit knee joint model were abolished by neutrophil depletion.
    • Intra-articular injection of neutrophils reconstituted the Arthus lesions.
    • Depletion of complement components reduced the rate and degree of joint injury.

    Conclusions:

    • Neutrophils are critical mediators of immune complex-induced Arthus vascular lesions in the rabbit knee joint.
    • Complement components play a significant role in the pathogenesis of immunologic joint injury.
    • This model is effective for studying acute immunologic arthritis and evaluating therapeutic interventions targeting neutrophils and complement.

    Related Experiment Videos