Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis.

Matilde Inglese1, Belinda S Y Li, Henry Rusinek

  • 1Department of Radiology, New York University School of Medicine, New York, New York 10016, USA.

Magnetic Resonance in Medicine
|June 20, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct Hippocampal Cellular Pathologies Influence Cognition Across Diagnostic Categories, Also Distinguishing Schizophrenia from Affective Psychoses.

bioRxiv : the preprint server for biology·2026
Same author

Amygdala microstructural changes in subjective cognitive decline: A diffusion kurtosis and neurite orientation dispersion and density imaging study.

Journal of Alzheimer's disease : JAD·2026
Same author

Hypertension is related to a slower radiotracer removal from lateral ventricles.

bioRxiv : the preprint server for biology·2026
Same author

Do Symptom Domains Have Similar Cellular Underpinnings Across Psychiatric Diagnoses: Evidence from 3D Hippocampal MR Spectroscopy.

bioRxiv : the preprint server for biology·2026
Same author

Association of plasma biomarkers with amyloid and tau PET in pre-dementia stages.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Cross-sectional investigation of choroid plexus calcification, cardiovascular risk score, and APOEε4 Status in cognitively normal cohort.

Cerebral circulation - cognition and behavior·2026
Same journal

Feasibility and SNR Performance of Hyperpolarized <sup>129</sup>Xe Gas Exchange Imaging Using a Balanced SSFP Sequence.

Magnetic resonance in medicine·2026
Same journal

Multi-Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration.

Magnetic resonance in medicine·2026
Same journal

Suppression of Oscillation and Ghosting in RF-Spoiled Gradient-Echo-Based Dynamic Imaging.

Magnetic resonance in medicine·2026
Same journal

A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp-Logan.

Magnetic resonance in medicine·2026
Same journal

7T 3D-EPI PCASL With High SNR Efficiency and Robustness to Through-Plane B<sub>0</sub> Field Gradients.

Magnetic resonance in medicine·2026
Same journal

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

Magnetic resonance in medicine·2026
See all related articles

Multiple sclerosis (MS) shows ongoing disease activity even without symptoms. Elevated choline and creatine in normal-appearing white matter (NAWM) indicate inflammation and may predict future MS progression.

Area of Science:

  • Neuroimaging
  • Metabolic studies
  • Neurology

Background:

  • Multiple sclerosis (MS) pathogenesis persists during clinically silent periods.
  • Quantifying metabolic changes in normal-appearing white matter (NAWM) is crucial for understanding MS activity.

Purpose of the Study:

  • To compare absolute metabolite levels (N-acetylaspartate, creatine, choline) in NAWM between relapsing-remitting MS patients and controls.
  • To identify metabolic markers indicative of subclinical MS activity.

Main Methods:

  • 3D proton MR spectroscopy at 1.5 T was used to measure metabolite concentrations in a 480 cm(3) volume-of-interest (VOI) centered on the corpus callosum.
  • 11 relapsing-remitting MS patients and 9 matched controls were included.
  • MRI segmentation was used to obtain gray/white matter and CSF volumes.

Related Experiment Videos

Main Results:

  • MS patients showed significantly different metabolite levels in NAWM compared to controls: N-acetylaspartate (NAA) -8%, creatine (Cr) -9%, and choline (Cho) +22%.
  • Choline levels were the only metric differentiating patients from controls with 100% specificity and >90% sensitivity.
  • Elevated Cho and Cr in NAWM suggest widespread microscopic inflammation, gliosis, or de-/remyelination.

Conclusions:

  • Elevated choline and creatine in NAWM are potential indicators of current MS disease activity.
  • These metabolites may precede N-acetylaspartate decline and brain atrophy.
  • Metabolic profiling of NAWM offers prognostic insights into MS progression.