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Updated: Jul 12, 2026
15:16
Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
Published on: July 22, 2012
Calicivirus infections in children.
1Center for Pediatric Research, Eastern Virginia Medical School and Children's Hospital of The King's Daughters, Norfolk, Virginia 23510, USA. dmatson@chkd.org
Current Opinion in Infectious Diseases
|June 25, 2003
Summary
Caliciviruses cause significant human illness and are emerging as a concern in biodefense. New research identifies recombinant Norovirus strains and highlights unexpected contamination sources, necessitating refined detection methods for Norovirus and Sapovirus.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Caliciviruses are a significant cause of human illness and are classified as Category B biodefense pathogens.
- They are frequently transmitted through contaminated food and water, leading to numerous outbreaks.
Purpose of the Study:
- To review recent advancements in understanding caliciviruses, including nomenclature changes and the emergence of recombinant strains.
- To discuss the implications of calicivirus diversity and recombination for diagnostics and epidemiology.
- To highlight evolving insights into outbreak sources and detection methods.
Main Methods:
- Review of recent literature on calicivirus nomenclature, genetics, and epidemiology.
- Analysis of findings related to recombinant Norovirus strains and potential inter-viral recombination.
- Examination of evolving strategies for identifying outbreak sources and improving diagnostic assays.
Main Results:
- New genera Norovirus (formerly Norwalk-like viruses) and Sapovirus (formerly Sapporo-like viruses) were established in 2002.
- Caliciviruses exhibit high genetic and antigenic diversity, complicating diagnostics but aiding outbreak investigations.
- Naturally occurring, virulent recombinant Norovirus strains have been identified and are widespread.
Conclusions:
- Ongoing investigations focus on identifying calicivirus outbreak sources, with increasing attention to unexpected sources like bottled water.
- Refined detection methods are crucial for managing calicivirus outbreaks.
- Parallels with Salmonella epidemiology may offer insights into Norovirus ecology and transmission.
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