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[The effect of proinflammatory cytokines in pathogenesis of chronic sinusitis]
Yanzhong Li1, Zhensheng Fang, Zhihua Du
1State Otolaryngology Institute, P. R. China Shandong University, Jinan 250012.
Objective:
To investigate the effect of the proinflammatory cytokines, including IL-1, IL-8 and TNF in the pathogenesis of chronic sinusitis.
Method:
Using immunohistochemical streptavidin-biotin peroxide complex (SABC) method to investigate the expression of interleukin-1 (IL-1), IL-8 and tumor necrosis factor (TNF) in the local mucosa of the two type chronic sinusitis.
Result:
There were significantly large numbers of IL-1+, IL-8+ and TNF+ cell in chronic sinusitis type I compared with healthy control (P < 0.01). The numbers of IL-8+ and TNF+ cell in the chronic sinusitis type II were significantly larger than that in the healthy control (P < 0.01). The numbers of IL-1+ cell in chronic sinusitis type I were significantly larger than that in chronic sinusitis type II (P < 0.01).
Conclusion:
This study indicates that proinflammatory cytokines may play an important role in the pathogenesis of chronic sinusitis. It appears that specific cytokine patterns are found in different forms of sinusitis. The investigation of different cytokine patterns may help to understand the different pathogenesis in chronic sinusitis subgroups.